![]() ![]() Effects of corticosteroids on 28-day mortality according to whether patients received invasive mechanical ventilation (IMV) at the time of randomizationĮFigure 2. Summary of assessments of the risk of bias in the estimated effect of corticosteroids on mortality in the METCOVID trialĮFigure 1. Characteristics of patients included in the METCOVID trialĮTable 4. Characteristics of the METCOVID trialĮTable 3. ![]() Summary of assessments of the risk of bias in the estimated effect of corticosteroids on mortality and serious adverse events in each trial, with brief explanation of judgementsĮTable 2. Lists of investigators and steering committeeĮTable 1. The prespecified primary analysis was the fixed-effect analysis, which should be used to guide clinical interpretation of the results. The 95% CI for the average effect (shown here) is wide because there is a small number of studies, some of which have very small sample size. CAPE COVID indicates Community-Acquired Pneumonia: Evaluation of Corticosteroids in Coronavirus Disease CoDEX, COVID-19 Dexamethasone COVID STEROID, Hydrocortisone for COVID-19 and Severe Hypoxia DEXA-COVID 19, Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 REMAP-CAP, Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia Steroids-SARI, Glucocorticoid Therapy for COVID-19 Critically Ill Patients With Severe Acute Respiratory Failure.ĪThe random-effects analysis estimates both the average and variability of effects across studies. The Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial result is for patients who were receiving invasive mechanical ventilation at randomization. ![]() The area of the data marker for each trial is proportional to its weight in the fixed-effect meta-analysis. ![]()
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Deadpool actor1/3/2023 ![]() ![]() ![]() New brands come into favor, fall out of favor, and go bankrupt all the time. For example: What happens if a consumer doesn't buy a second bottle? What if instead of a bottle of Aviation, they go on to try the next novelty alcohol instead, and the 100% sales growth Aviation saw last year starts to slow?Ĭonsumers can be fickle with their discretionary spending, after all. Aviation, for example, enjoyed better than 100% sales growth the year after Reynolds bought into it.Īlmost certainly, part of that growth came from consumers intrigued by Reynolds' involvement in the project and willing to buy a bottle to see what all the fuss was about.īut even so, I think there are lessons investors can learn from Reynolds' investments. Moreover, Reynolds is able to leverage the star power of his name to grow the value of the brands he invests in. Both Aviation and Mint were, after all, private companies, and few ordinary investors have access to those kinds of opportunities. Granted, not everyone can make these kinds of investments. What investors can learn from Ryan Reynolds If this is how things play out, Mint may become Reynolds' next winning investment. In November last year, Reynolds revealed he had purchased a large interest (reportedly more than 25%) in discount prepaid cellphone service provider Mint Mobile.Įven Reynolds acknowledged that his move into wireless telephony is a bit "unconventional." So why make the switch from premium gin to prepaid cell service?Īs Reynolds said in the company's announcement at the time, "the average American is paying 65 dollars a month" for telephone service that is "most essential." But by piggybacking aboard the cell network of T-Mobile US ( NASDAQ:TMUS), and T-Mobile's infrastructure to carry Mint's service, Mint Mobile is able to provide "premium wireless" service to its customers for as little as $15 a month.Ī rate that low could help Mint steal market share among budget-conscious consumers and outgrow bigger rivals such as AT&T, Verizon, and T-Mobile itself. From premium gin to plebeian phone serviceĮven before the Aviation Gin sale was announced - perhaps even before negotiations had begun - Reynolds was already working on a second major investment, and this one headed in an entirely different direction. But even if he owned as little as 10% of the company (for example), $610 million divided by 10 would still be a lot of money - certainly more money than the $2 million he was paid for starring in Deadpool.Īnd Reynolds didn't stop there. Now, because Reynolds' initial investment in Aviation Gin was never disclosed, and because we likewise don't know what percentage of Aviation Gin he acquired for that investment, it's impossible to say precisely how much of the $610 million will be going into Reynolds' pocket. ![]() Firefox har viewer1/3/2023 ![]() ![]() Open Network monitor by pressing Ctrl+Shift+E or F12 (in Windows) or Command+ Option+Q (on Mac).Specify where to save the log and click Save.After reproducing the issue, click on Export HAR:.Click to select the Preserve Log check box:.Press F12 to open Developer Tools windows, and then click the Network tab:.Collecting log in Google Chrome or Microsoft Edge ![]() Acronis Agent or other Acronis Backup components are not required for HAR log collection. HAR log should be collected from the machine from which you are trying to connect to web console. This information is required for troubleshooting web console issues in Acronis products. HAR (HTTP Archive format) is a log of a web browser's interaction with a site. ![]() Razia sultan1/3/2023 ![]()
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Turned out he was better suited for our friend anyway, and they ended up getting married, which I am so thankful for because they are one of the few couples I know who support each other through everything. We had the music thing in common, surely he’d be interested in me. (See? Even back then I was hopelessly drawn to musician types.) I turned up for a friend’s birthday party where I was supposed to meet this guy, but he only had eyes for another one of our friends. So much that one of them tried to set me up with a guy they knew who boasted he could play the song on guitar and he knew all the words too. It became so large in my ‘mythology’ (I’m being sarcastic that’s why mythology has single quotes around it) that my girlfriends all knew how much I loved that song. I pick up song lyrics quickly, and in a world where we generally only listened to regular radio on boomboxes and the internet had barely become a thing, ‘Semisonic’ quickly became one of those tunes that I had on repeat not only on my pathetic sound system at school, but also in my head. The song spoke to me instrumentally first, with the lyrics feeling right for the music, but its meaning didn’t really come to me until I started thinking about what songs I might want to analyse on Music in Notes in 2014. To say that ‘Closing Time’ by Semisonic was a song that defined my and my friends’ lives in school would be an understatement. And knew when to break out the air guitar during the solo. There is a small group of songs, definitely numbering less than 10, that I would say I recall sitting in the back of one of our friends’ cars, with the radio turned way up, and everyone knew all the words too. Where to find it: ‘Feeling Strangely Fine’ (1998, MCA) Also, seeing that the writer has already explained the meaning of his song, this post is now closed to comments. Personally, I think it’s strange anyone would use anything related to a bar and drinking as a metaphor for the birth of a baby, but that’s artistic license. ![]() A woman with a science background (doubly weird, considering my main vocation) wrote a post a couple days ago, reminiscing about the birth of one of her children, tying this event in with Dan Wilson explaining in 2008 what the song is about. ![]() Update 18/01/15: this past weekend, this post was inexplicably barraged by comments, which I thought was a bit strange, given that I posted it on Music in Notes a year ago. ![]() F1 2018 ps4 review1/3/2023 ![]() You can play all the way through F2’s 2018 season – competing against Lando Norris, Alexander Albon and George Russell, who all entered Formula One this year. As with all annual sports games – such as EA Sports’ Fifa – each new iteration will only ever bring incremental improvements, but there are some welcome new elements in F1 2019, and the sheer quality of its execution is more evident than ever.īut the biggest addition is Formula One’s feeder series, F2. ![]() And a decade since Warwickshire-based developer Codemasters started making video games based on the pinnacle of motorsports, it’s fair to say that the studio has cracked it. 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